I can lose weight but it's a real uphill struggle.
When this is the case, the families caring for them are faced with an uphill struggle, as it is difficult to reconcile the need for earning a living with the care of their relatives. (Certificate of Proficiency in English; C2; Greek)
We'd walked half a mile uphill.
She had not seen the lorry that made [its] way uphill and when she realized that she would crash right into it, it had been to[o] late to do something. (Certificate of Proficiency in English; C2; Dutch)